Lupeol health benefit and study review

Lupeol type saponin derivatives include lupane, betulinic acid, and betulin.

Where is lupeol found?
Pentacyclic lupane-type triterpenes exemplified by lupeol  are principally found in common fruit plants such as olive, mango fruit, fig, etc.

Lupeol health benefit
Lupeol has many biological activities like anti-inflammatory, anti-arthritic, anti-mutagenic and anti-malarial activity both in in vitro and in vivo systems.

Lupeol for liver cancer
Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis through down-regulation of DR3 in SMMC7721 cells.
Cancer Invest. 2009 Feb;27(2): Department of Surgery, Lanzhou University Second Hospital, Gansu Province, China.
Lupeol (Lup-20(29)-en-3H-ol), a novel dietary triterpene, was found in fruits, vegetables, and several medicinal plants. Here, we investigated its growth-inhibitory effect and associated mechanisms in hepatocellular carcinoma SMMC7721 cells. Lupeol treatment resulted in significant inhibition of cell viability in a dose-dependent manner and caused apoptotic death of this cell line with activation of caspase3 expression. Our results suggested that Lupeol treatment induced growth inhibition and apoptosis in SMMC7721 cells, the mechanism is due to down-regulation of Death receptor 3 expression. We demonstrated that Lupeol appears to be a promising chemopreventive agent for treating hepatocellular carcinoma, and DR3 may be an important target for liver cancer therapy.

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