Lupeol health benefit and study review
Lupeol type saponin derivatives include lupane, betulinic acid, and betulin.
Where is lupeol found?
Pentacyclic lupane-type triterpenes exemplified by lupeol are principally found in common fruit plants such as olive, mango fruit, fig, etc.
Lupeol health benefit
Lupeol has many biological activities like anti-inflammatory, anti-arthritic, anti-mutagenic and anti-malarial activity both in in vitro and in vivo systems.
Lupeol for liver cancer
Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis through down-regulation of DR3 in SMMC7721 cells.
Cancer Invest. 2009: Department of Surgery, Lanzhou University Second Hospital, Gansu Province, China.
Here, we investigated its growth-inhibitory effect and associated mechanisms in hepatocellular carcinoma SMMC7721 cells. Lupeol treatment resulted in significant inhibition of cell viability in a dose-dependent manner and caused apoptotic death of this cell line with activation of caspase3 expression. Our results suggested that Lupeol treatment induced growth inhibition and apoptosis in SMMC7721 cells, the mechanism is due to down-regulation of Death receptor 3 expression. We demonstrated that Lupeol appears to be a promising chemopreventive agent for treating hepatocellular carcinoma, and DR3 may be an important target for liver cancer therapy.
lutein eye home and ways to see better without glasses
Chemical constituents of Periploca forrestii and their
Zhongguo Zhong Yao Za Zhi. 2009. The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
To investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities. Silica gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor (HL-60, CCRT-CEM), prostate tumor (PC-3, DU-145) and Melanoma (UACC-62). Four compounds were isolated and identified as follows, lupeol-20(29)-en-3-nonadecanoate (1), peroiforoside I (2), 3beta,5beta,14beta-3OH-8beta-H-car-20(22)-enolide (3), perplocin. Compound 1 is a new lupane triterpene fatty acid ester. Compounds 2-4 showed notable cytotoxicity against all tumor lines.