Lucidenic acid benefit and side effects, found in reishi muhroom

Ganoderma lucidum is known as a medicinal mushroom that contains lucidenic acid.

Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway.
J Agric Food Chem. 2008; Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung, Taiwan.
Ganoderma lucidum is known as a medicinal mushroom used in traditional Chinese medicine. In the present study, the effect of lucidenic acids (A, B, C, and N) isolated from a new G. lucidum (YK-02) on induction of cell apoptosis and the apoptotic pathway in HL-60 cells were investigated. The results demonstrated that lucidenic acids decreased cell population growth of HL-60 cells. Our finding may be critical to the chemopreventive potential of lucidenic acid B.

Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity.
Arch Pharm Res. 2009. College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Korea.
To determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide, ergosterol, genoderic acid Sz, stella sterol, ganoderic aic C1, ganoderic acid A, methyl ganoderate A, and lucidenic acid A based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC50 values of 52.0 and 44 microM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 microM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the delta7(8), delta9(11)-lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

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