Limonene health benefit

Limonene is a terpene with an extremely strong smell of oranges. Limonene takes its name from the lemon, as the rind of the lemon, like other citrus fruits, contains considerable amounts of this chemical compound, which is responsible for much of their smell.

Limonene in Huajiao fruit
The two most commercially popular species of huajiao fruit are bungeanum (red huajiao) and schinifolium (green huajiao). Fresh huajiao has a very high content of essential oil, up to 11%, which is described as having fresh, spicy, floral, cooling, and green aroma notes. A comprehensive analysis of the essential oils showed a total of 120 aromatic compounds for each species. Linalyl acetate (15%), linalool (13%), and limonene (12%) are the major components of red huajiao, whereas linalool (29%), limonene (14%), and sabinene (13%) are the major components of green huajiao.

Limonene as potential use in cancer
Mechanism of the antiproliferative action of limonene on a lymphoma cell line: participation of nitric oxide. antiproliferative action of limonene on a lymphoma cell line.
Phytother Res. 2009 Jan 14. Manuele MG, Arcos ML, Davicino R, Ferraro G, Cremaschi G, Anesini C. Manuele MG, Arcos ML, Davicino R, Ferraro G, Cremaschi G, Anesini C. IQUIMEFA-CONICET, Faculty of Pharmacy and Biochemistry, UBA, Junin 956 (1113) Buenos Aires, Argentina.
Previously limonene demonstrated antiproliferative action on a lymphoma cell line (BW5147). The objective of this study was to investigate the mechanism of the antiproliferative action of limonene on BW 5147 cells. Limonene exhibited antiproliferative action on tumoral lymphocytes exerting a decrease in cell viability that was related to apoptosis induction and to the increase in nitric oxide levels at long incubation times. At short times and depending on its concentration, limonene arrested cells in different phases of the cell cycle, related to NO production.

Does grape seed extract have limonene substance?
   We don't know at this time.

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